I like the design of this pendant by Fraser Hamilton Jewellery and they do several pieces using a hand motif.
The designer explains, “A finely-detailed hand clutches a crisp natural Tanzanian red pear cut sapphire. Materials: 14k gold, sapphire 0.4ct. Pendant size: adjustable 14k chain 18-20″, pendant 1.5 cm. Additional details: Please kindly note that 14k hand pendants are hand-crafted with specially selected ruby or sapphire gemstones thus every design is unique. For custom orders of something similar the exact orientation of the gemstone may vary slightly; however, it will always be set in the most secure way.”
This is priced at £1,080.